Using a ballistics calculator, with a .452 diameter 200 gr. hollow point bullet @ 950 fps, with sights 1" over bore axis, sighted at 100 yards on a 65d day with no wind.....(heavy sigh)....... at 50 yards the bullet will impact 5" above
the bore axis. At 150 yards the bullet impact will be 17.33" below
the bore axis. At 200 yards the bullet impact will be 48.33" below
bore axis....... and so on.
That's really lobbing it out there. You'd have to be very, very good at estimating hold-over beyond 100 yards.
ETA: This is only an example of .45 ballistics. It does not reflect actual FPS, bullet type used, actual temperature, sight above bore height, or a more realistic sight-in range of 50 yards.