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38 is way more economical for plinking and genral shooting. for home defense some will say its too anemic but i carry a .22 LR for self defense an never feel undergunned so i may be biased. shoot what you like, what you;re comfortable with and what fits your budget. a 44 specail would be significantly expensive to shoot unless you reload.

Thanks, I was kinda worried about the price of ammunition. I have thought about using a 22Lr for plinking and defence but the size of the caliber has kept me from using it. By the way what model is your 22?
If i toted a .22 id use CCI Stinger of Velocoraptor or those 3000 fps winchester .22 lr rounds. Even CCI Mini mag1260 fps hollows if need be.
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