It would be entertaining to fire such a round out of a carbine but the cost and recoil would be excessive.
would be a decent bear defense gun though.
Hi-Point need to design a new carbine that operates from a gas-piston, they would have to lighten the slide/bolt on the carbine so it could be manipulated by the piston, it's really not a big modification to the existing design, rhis would make all sorts of caliber weapons feasible.