There have been lots of threads about which round is best 9, 40, 45, etc... When I first started shooting handguns I thought nothing compared to .45 acp. I even once posted here that "mathematically" the .45 was the superior round. As the years passed, I began to realize that all rounds have good and bad points, and that many are very similar in real life. Today I started looking up info and comparing the .380 through .45. Here is a table summarizing what I found. As far as I can tell the data comes from rounds fired through a 4 inch barrel. Although it is obvious the .380 is low man on the list, there is a lot of overlap on the list. I did notice one mistake though. Buffalo Bore makes a 200 grain .40 that isn't on the list.