There has been lots of talk the last few months about how deadly the small rounds are 22lr, 25, and .380... The thing to remember is all rounds can kill or maim, that is a given. The real point is about how much time it could take those rounds to remove a BG's capability for doing you harm. (without a head or upper spine shot). If you are engaging a BG with one of those rounds who is firing at you with a 9mm, 40S&W, or 45acp there is a very good chance he will drop you even after you have shot him. Though in the long run you might have ended up killing him.